Seminars - Ray and Stephanie Lane Center for Computational Biology - Carnegie Mellon University

Upcoming Seminars

9/26/2014
Laxmi Parida

Comp. Genomics, IBM T.J. Watson Research Center

Population Genomics under the lens of Random-Graphs
The  modeling of evolutionary dynamics of  populations as random graphs offers a new direction of exploration.  We also introduce the notion of a minimal descriptor of an Ancestral Recombination Graph (ARG)  that can be used for measuring redundancy as well as  extent-of-reconstructability of ARGs. I will discuss how we have used ARGs, constructed from extant samples (using a pipeline called IRiS), to address many fascinating questions ranging from human migration paths, to genetic diversity study in plant cultivars. The combinatorial viewpoint also paves the way for extremely fast, as well as accurate, ARG sampling algorithms (called SimRA).  I will conclude with a discussion of our exploration of persistent homology on ARGs to study admixture in populations: both on SimRA samples and plant cultivars.


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